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Methyl iodide → 4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | beta,beta-Dimethyl-1H-indole-3-ethanamine | HCID 27303 | — |
| 反応物 | tert-Butyl 3-(cyanomethyl)-1H-indole-1-carboxylate | HCID 15378323 | — |
| 生成物 | 4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester | HCID 66640193 | — |
反応手順
4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester was prepared in a manner similar to that described in Example 66A by replacing tryptamine-HCl with 2-(1H-indol-3-yl)-2-methylpropylamine, which was synthesized using 2 equivalents of iodomethane during alkylation of (1-tert-butoxycarbonylindol-3-yl)acetonitrile as described in Example 32B; MS(ESI): 273(MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07485634B2 |
| 出典データセット | uspto-grants-2009_02 |
| ORD ID | ord-a971a8d9f3624726a4b729c4df358154 |
| 出典メモ | uspto-grants-2009_02 |