関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cyanamide | HCID 9864 | — |
| 反応物 | 3-Benzyloxyaniline | HCID 92892 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | HCID 178419031 | HCID 178419031 | 37.3% |
反応手順
3-benzyloxy aniline (1 g, 5 mmol) and cyanamide (420 mg, 10 mmol) were dissolved in 4 mL of 4N HCl in dioxane and heated to 120° C. overnight. The reaction mixture was cooled to room temperature, quenched with water, and extracted with diethyl ether. The aqueous layer was made basic with 2N NaOH and extracted thrice with dichloromethane. The organic extracts were combined and washed with brine, dried over MgSO4, and concentrated to afford 4 (450 mg) as a light brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07488727B2 |
|---|
| 出典データセット | uspto-grants-2009_02 |
|---|
| ORD ID | ord-62d63ae235024c47abb0b5e832a8f814 |
|---|
| 出典メモ | uspto-grants-2009_02 |
|---|
