関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ziprasidone | HCID 60854 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Ziprasidone Hydrochloride | HCID 219099 | — |
反応手順
Ziprasidone (5 g) and 50 mL of acetic acid were placed into a round bottom flask and heated to 45-50° C. Added was 25 mL of aqueous hydrochloric acid slowly to the mixture over 20 min. Then the reaction mixture was refluxed. Water (10 mL) was added, followed by addition of 50 mL of Isopropanol. The reaction mass was cooled to 50° C. and distilled off the solvent completely under vacuum. The material formed was scratched from the flask.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07488729B2 |
|---|
| 出典データセット | uspto-grants-2009_02 |
|---|
| ORD ID | ord-9e5bbee97d30450b80ddca42bd2496c4 |
|---|
| 出典メモ | uspto-grants-2009_02 |
|---|
