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p-Toluenesulfonic acid → 3-Oxo-3-(4-propyl-cyclohexyl)-propionic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | 2-(4-Propyl-cyclohexanecarbonyl)-malonic acid diethyl ester | HCID 69059980 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Sodium chloride; water | HCID 57417360 | — |
| 生成物 | 3-Oxo-3-(4-propyl-cyclohexyl)-propionic acid ethyl ester | HCID 57423720 | 83.1% |
反応手順
A solution of 3.0 g (9.6 mmol) 2-(4-propyl-cyclohexanecarbonyl)-malonic acid diethyl ester and 0.3 g p-toluenesulfonic acid in 30 mL water was heated to reflux for 3 hr and allowed to stand at room temperature over 3 nights. The reaction was diluted with brine, extracted with ethyl acetate, dried over MgSO4, and concentrated to afford 1.92 g (7.98 mmol) 3-oxo-3-(4-propyl-cyclohexyl)-propionic acid ethyl ester as a clear oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07488832B2 |
| 出典データセット | uspto-grants-2009_02 |
| ORD ID | ord-558f46d2fb8848a4838ed154cdc61d50 |
| 出典メモ | uspto-grants-2009_02 |