3-Aminopyridine → 5-Acetyl-2-ethyl-6-phenyl-4-(pyridin-3-ylamino)pyridazin-3(2H)-one

HRID 1725519

反応式

HRID 1725519 の反応式
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].N[C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:23]1[CH:24]=[N:25][CH:26]=[CH:27][CH:28]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 100093-AminopyridineHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

生成物 1

HCID 684882995-Acetyl-2-ethyl-6-phenyl-4-(pyridin-3-ylamino)pyridazin-3(2H)-one収率 26%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 200 mg (0.7 mmol) of 5-acetyl-2-ethyl-4-nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al, J. Med. Chem. 1997, 40, 1417) in ethanol (10 mL), 3-aminopyridine (0.098 mg, 1.04 mmol) was added portionwise. The resulting mixture was stirred at room temperature for five hours. The solvent was evaporated and the residue purified by column chromatography (silica gel, dichloromethane/methanol 97:3) to yield the title compound (60 mg, 26% yield).

後処理

  1. customThe solvent was evaporated
  2. customthe residue purified by column chromatography (silica gel, dichloromethane/methanol 97:3)

出典と根拠

ORDレコード
ord-42fe29e1a82b47c69a290948a3699c8c
出典データセット
uspto-grants-2009_02
特許番号
US07491722B2

関連ノート

読み込み中…