3-Amino-5-methylisoxazole → 5-Acetyl-2-ethyl-4-[(5-methylisoxazol-3-yl)amino]-6-phenylpyridazin-3(2H)-one

HRID 1725542

反応式

HRID 1725542 の反応式
[C:1]([C:4]1[C:9]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[N+:19]([O-])=O)(=[O:3])[CH3:2].N[C:23]1[CH:27]=[C:26]([CH3:28])[O:25][N:24]=1>C(O)C>[C:1]([C:4]1[C:9]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)=[N:8][N:7]([CH2:16][CH3:17])[C:6](=[O:18])[C:5]=1[NH:19][C:23]1[CH:27]=[C:26]([CH3:28])[O:25][N:24]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 661723-Amino-5-methylisoxazoleHCID 107320155-acetyl-2-ethylnitro6-phenylpyridazin-3(2H)-one

生成物 1

HCID 684884685-Acetyl-2-ethyl-4-[(5-methylisoxazol-3-yl)amino]-6-phenylpyridazin-3(2H)-one収率 37.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a stirred solution of 80 mg (0.278 mmol) of 5-acetyl-2-ethyl nitro-6-phenylpyridazin-3(2H)-one (Dal Piaz, V et al., J. Med. Chem. 1997, 40, 1417) in ethanol (4 mL), 3-amino-5-methylisoxazol (96 mg, 0.978 mmol) was added. The resulting mixture was stirred, at room temperature for four days and the final product was collected by filtration and washed with diethylether to yield the title compound (35 mg, 37.2% yield).

後処理

  1. filtrationthe final product was collected by filtration
  2. washwashed with diethylether

出典と根拠

ORDレコード
ord-ca5665ef37d84a5b8462c7b3679d20f7
出典データセット
uspto-grants-2009_02
特許番号
US07491722B2

関連ノート

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