Hydrochloric Acid → 4-(1H-Imidazol-2-yl)piperidine dihydrochloride
反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7]1.[ClH:19]>CO>[ClH:19].[ClH:19].[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH:6]1[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1参加物
4
実験手順
A solution of tert-butyl 4-(1H-imidazol-2-yl)piperidine-1-carboxylate (5.5 g) in methanol was saturated with HCl and the mixture was left standing overnight. Evaporation give the product in quantitative yield. 1H NMR (400 MHz, D2O): 7.29 (s, 2H), 3.51 (br. d, J=13 Hz, 2H), 3.47-3.40 (m, 1H), 3.12 (br. t, J=13 Hz, 2H), 2.29 (br. d, J=14 Hz, 2H), 2.04-1.92 (m, 21).
後処理
- waitthe mixture was left
- customEvaporation
- customgive the product in quantitative yield
出典と根拠
- ORDレコード
- ord-73dc8929c73247ff81ff4ce59d50f92a
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07491737B2
反応ノート
読み込み中…