1-Boc-4-[Hydroxy-(4-trifluoromethoxyphenyl)methyl]piperidine → tert-Butyl 4-(4-(trifluoromethoxy)benzoyl)piperidine-1-carboxylate

HRID 1726241ノート

反応式

HRID 1726241 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]([OH:26])[C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O>C(Cl)Cl>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14](=[O:26])[C:15]2[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:19][CH:20]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 120527841-Boc-4-[Hydroxy-(4-trifluoromethoxyphenyl)methyl]piperidineHCID 178418287HCID 178418287、化合物

生成物 1

HCID 68968884tert-Butyl 4-(4-(trifluoromethoxy)benzoyl)piperidine-1-carboxylate収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4-[hydroxy-(4-trifluoromethoxy-phenyl)-methyl]-piperidine-1-carboxylic acid tert-butyl ester (see EXAMPLE 32) (604 mg, 1.61 mmol) in CH2Cl2 (8 mL) was added SiO2 (2 g) followed by PCC (1.04 g, 4.82 mmol), and the mixture was stirred at room temperature for 3 h to give 4-(4-trifluoromethoxy-benzoyl)-piperidine-1-carboxylic acid tert-butyl ester as colourless crystals (601 mg, 100%) after purification.

出典と根拠

ORDレコード
ord-aa4a1224a10c4668b12cbc71c6360b25
出典データセット
uspto-grants-2009_02
特許番号
US07491735B2

反応ノート

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