Phosphorus tribromide → 3-(Bromomethyl)-4-methoxythiophene
反応式
P(Br)(Br)[Br:2].[CH3:5][O:6][C:7]1[C:8]([CH2:12]O)=[CH:9][S:10][CH:11]=1>C(Cl)Cl>[Br:2][CH2:12][C:8]1[C:7]([O:6][CH3:5])=[CH:11][S:10][CH:9]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a solution of phosphorous tribromide (271 mg, 1.00 mmol) in CH2Cl2 (1.5 mL) cooled to 0° C. was added a solution of the above alcohol (144 mg, 1.00 mmol) in CH2Cl2 (1.5 mL) and the solution was stirred at 0° C. for 5 minutes to give 3-bromomethyl-4-methoxy-thiophene as an oil (200 mg, 97%) after work-up.
出典と根拠
- ORDレコード
- ord-6a897e49a37f4753b31977572fe3275c
- 出典データセット
- uspto-grants-2009_02
- 特許番号
- US07491735B2
反応ノート
読み込み中…