Water → (2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

HRID 1726325ノート

反応式

HRID 1726325 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:7]=[C:8]([CH3:10])[CH:9]=1)[CH:5]=O.C1C=CC([CH:17]([NH2:20])CO)=CC=1.[OH2:21].[C:22]1([CH3:28])[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:27]1([C@@H:22]([CH:28]=[CH:5][C:4]2[CH:3]=[C:2]([CH3:1])[CH:9]=[C:8]([CH3:10])[CH:7]=2)[CH2:23][OH:21])[CH:26]=[CH:25][CH:24]=[N:20][CH:17]=1

参加物

5

反応物 4

HCID 962WaterHCID 1140TolueneHCID 34225Benzaldehyde, 3,5-dimethyl-HCID 924662-Amino-2-phenylethanol

生成物 1

HCID 68464252(2r)-3-Aza-2-phenyl-4-(3,5-dimethylphenyl)but-3-en-1-ol

実験手順

A solution of 3,5-dimethylbenzaldehyde (30.0 g) and (R)-phenylglycinol (30.7 g) in toluene (200 ml) was refluxed for 3 hours with removing water. The reaction solution was concentrated to give the title compound (59.7 g) having the following physical data.

後処理

  1. concentrationThe reaction solution was concentrated

出典と根拠

ORDレコード
ord-e7f2b641c56243259bebfb11b0aea8ae
出典データセット
uspto-grants-2009_02
特許番号
US07491748B2

反応ノート

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