Hydrochloric Acid → HCID 23154471、化合物

HRID 1726882ノート

反応式

HRID 1726882 の反応式
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28]5(OCC[O:29]5)[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].C([O-])(O)=O.[Na+].[ClH:40]>>[ClH:40].[ClH:40].[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:15]=[CH:14][C:13]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([N:25]4[CH2:34][CH2:33][C:28](=[O:29])[CH2:27][CH2:26]4)(=[O:24])=[O:23])=[CH:18][CH:17]=3)=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 231544778-[[4-[6-[4-(1-Methylethyl)-1-piperazinyl]-3-pyridinyl]phenyl]sulfonyl]-1,4-dioxa-8-azaspiro[4.5]decane

生成物 1

HCID 23154471HCID 23154471、化合物

反応条件

温度
80 °C

実験手順

A suspension of 400 mg of the product obtained in Step C (0.82 mmol) in 5 ml of 1N HCl is stirred for 1 hour at 80° C. After neutralisation of the reaction mixture using 10% NaHCO3, the precipitate is filtered off, washed with water and dried. The white solid is suspended in ethanol and dissolved by adding methanolic HCl. The solution is evaporated to dryness and the residue is taken up in an ethanol/ethyl ether mixture to yield the expected product after filtration.

後処理

  1. filtrationthe precipitate is filtered off
  2. washwashed with water
  3. customdried
  4. dissolutiondissolved
  5. additionby adding methanolic HCl
  6. customThe solution is evaporated to dryness

出典と根拠

ORDレコード
ord-a666c67b36b64f4ea169e11abf46ad8a
出典データセット
uspto-grants-2009_02
特許番号
US07494994B2

反応ノート

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