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HRID 1726913作成日：2026年10月25日
Potassium Carbonate → 3-(2-Chloro-5-nitro-phenyl)-1-methyl-7-methylsulfanyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one
https://huagongshe.com/reaction/1726913
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | {5-[(2-Chloro-5-nitro-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-methyl-amine | HCID 68700288 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3-(2-Chloro-5-nitro-phenyl)-1-methyl-7-methylsulfanyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one | HCID 68697893 | 96% |
反応手順
20.796 g {5-[(2-Chloro-5-nitro-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-methyl-amine were dissolved in 500 ml acetonitrile, 25.375 g potassium carbonate and 19.847 g N,N-carbonyldiimidazole (CDI) were added, and the solution was heated at 50° C. for 24 hrs. The solvent was dried over sodium sulfate, evaporated, and the residue was extracted with diethyl ether to give the title product in 96% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07494993B2 |
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| 出典データセット | uspto-grants-2009_02 |
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| ORD ID | ord-d61fb5a9b9c64b76af8e83a9a25f797a |
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| 出典メモ | uspto-grants-2009_02 |
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