Bromine → HCID 11696686、化合物

HRID 1727347ノート

反応式

HRID 1727347 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([C:8](=[O:17])[CH2:9][C:10]2[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[CH:11]=2)[CH:5]=[CH:6][CH:7]=1.[Br:18]Br>C(O)(=O)C>[BrH:18].[Br:18][CH:9]([C:10]1[CH:15]=[CH:14][N:13]=[C:12]([CH3:16])[CH:11]=1)[C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[CH:3]=1)=[O:17]

参加物

4

反応物 2

HCID 24408BromineHCID 116586421-(3-Methylphenyl)-2-(2-methyl-4-pyridyl)ethanone

生成物 1

HCID 11696686HCID 11696686、化合物収率 66%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
70 °C

実験手順

1-(3-methylphenyl)-2-(2-methyl-4-pyridyl)ethanone (150 g) was dissolved in acetic acid (450 mL), bromine (34.3 mL) was added to this, and the mixture was stirred for 3 hours at 70° C. The reaction solution was cooled by ice water, and the deposited crystal was filtrated off. The crystal was washed with ethyl acetate to obtain a title compound (168 g, yield 66%).

後処理

  1. filtrationthe deposited crystal was filtrated off
  2. washThe crystal was washed with ethyl acetate

出典と根拠

ORDレコード
ord-0dcce69f607642eebd1a9fb19f774751
出典データセット
uspto-grants-2009_02
特許番号
US07495018B2

反応ノート

読み込み中…