Potassium Carbonate → 5-Chloro-2-(3-hydroxy-propoxy)-benzaldehyde

関与物質

役割	名称	HCID	仕込み量
反応物	Potassium Carbonate	HCID 11430	—
反応物	3-Bromo-1-propanol	HCID 12308	—
反応物	5-Chloro-salicylaldehyde	HCID 12481	—
溶媒	Dimethylformamide	HCID 6228	—
生成物	5-Chloro-2-(3-hydroxy-propoxy)-benzaldehyde	HCID 57565935	59%

反応手順

5-Chloro-2-hydroxy-benzaldehyde (3.1 g, 20 mmol), 3-bromo-propan-1-ol (4.1 mL, 24 mmol), K2CO3 (5.5 g, 4 mmol) and KI (0.5 g) were mixed in DMF (20 mL). Then the mixture was irradiated under microwave at 200° C. for 1 h. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in ethyl acetate and washed with 1N NaOH. Then the organic layer was separated, dried over Na2SO4 and concentrated to give title compound (Yield: 1.7 g, 59%).

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07495007B2
出典データセット	uspto-grants-2009_02
ORD ID	ord-653dbb65be664e1fbbcc871c9d5ff7d6
出典メモ	uspto-grants-2009_02