Pyrrolidine → Z-6-chloro-3-[5-chloro-2-(3-hydroxy-propoxy)-benzylidene]-1,3-dihydro-indol-2-one

関与物質

反応条件

反応手順

5-Chloro-2-(3-hydroxy-1-propoxy)-benzaldehyde (8 g, 37 mmol) and 6-chlorooxindole (6.2 g, 37 mmol) were mixed in anhydrous methanol (20 mL). Then pyrrolidine (3 mL, 37 mmol) was added slowly at r.t. The mixture was heated to 70° C. for 3 h and cooled to room temperature. The precipitate was collected by filtration to give title compound as a yellow solid (Yield: 11.8 g).

情報源と証拠