1-Fluoro-2-methoxy-5-methyl-3-nitrobenzene → 3-Fluoro-2-methoxy-5-methylaniline

HRID 17286

反応式

HRID 17286 の反応式
[F:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[O:12][CH3:13]>[C].[Pd].CO>[F:1][C:2]1[C:3]([O:12][CH3:13])=[C:4]([CH:5]=[C:6]([CH3:8])[CH:7]=1)[NH2:9]

参加物

4

反応物 1

HCID 575758761-Fluoro-2-methoxy-5-methyl-3-nitrobenzene

生成物 1

HCID 451220523-Fluoro-2-methoxy-5-methylaniline収率 81.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

5% Palladium-carbon (wet, 100 mg) was added to a methanol (5 ml) solution of 1-fluoro-2-methoxy-5-methyl-3-nitrobenzene (I-25) (250 mg, 1.35 mmol), followed by stirring under hydrogen atmosphere for 30 minutes. After filtration and concentration under reduced pressure, the resulting residue was subjected to column chromatography, and the eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure to obtain the entitled compound (170 mg, 81%) as a yellow oily substance.

後処理

  1. filtrationAfter filtration and concentration under reduced pressure
  2. concentrationthe eluate with n-hexane:ethyl acetate (9:1) was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-51c75521558b47e6890a4a69c8e9f48b
出典データセット
uspto-grants-2010_06
特許番号
US07737166B2

関連ノート

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