N-Phenylglycine ethyl ester → ethyl 2-(N-phenylformamido)acetate

HRID 1728952ノート

反応式

HRID 1728952 の反応式
[CH2:1]([O:3][C:4](=[O:13])[CH2:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH3:2].[CH:14](OC(=O)C)=[O:15]>O>[CH2:1]([O:3][C:4](=[O:13])[CH2:5][N:6]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH:14]=[O:15])[CH3:2]

参加物

4

反応物 2

HCID 75190N-Phenylglycine ethyl esterHCID 75269Acetic-formic anhydride

生成物 1

HCID 14416604ethyl 2-(N-phenylformamido)acetate収率 70%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

N-Phenylglycine ethyl ester (100 g; 0-56 mol) was added in small portions to acetic formic anhydride (100 g; 1.14 mol) with vigorous stirring. The mixture was allowed to stir overnight, then it was poured into water, and extracted with ether. The ether solution was washed with sodium bicarbonate solution and then with water. The ether was evaporated in vacuo to give an oil which was distilled to give N-phenyl-N-formylglycine ethyl ester (81 g; 70%) having a bp 115°-117° C.

後処理

  1. extractionextracted with ether
  2. washThe ether solution was washed with sodium bicarbonate solution
  3. customThe ether was evaporated in vacuo
  4. customto give an oil which
  5. distillationwas distilled

出典と根拠

ORDレコード
ord-ab70f6dde5414ecabec30cbd5dd807d6
出典データセット
uspto-grants-1994_07
特許番号
US05329012

反応ノート

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