Acetic Acid → Diethyl 1-methyl-2-(methylthio)-1H-imidazole-4,5-dicarboxylate

HRID 1728957ノート

反応式

HRID 1728957 の反応式
[CH3:1][S:2][C:3]1[NH:4][C:5]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])[N:7]=1.[N+](=[CH2:20])=[N-].C(O)(=O)C>CCOCC>[CH3:20][N:7]1[C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[N:4]=[C:3]1[S:2][CH3:1]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 9550Diazomethane2 回HCID 14416595Diethyl 2-(methylsulfanyl)-1H-imidazole-4,5-dicarboxylate

生成物 1

HCID 303834Diethyl 1-methyl-2-(methylthio)-1H-imidazole-4,5-dicarboxylate収率 97%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

The diethyl 2-(methylthio)-4,5-imidazoledicarboxylate (10 g; 0.039 mol) was slowly added in small portions to a solution of diazomethane in ether (containing approximately 3 g of diazomethane). Nitrogen was evolved immediately and the solution was allowed to stand at room temperature overnight. Excess diazomethane was then decomposed by the addition of dilute acetic acid and the reaction mixture was worked up in the usual way. Diethyl 1-methyl-2-(methylthio)-4,5-imidazoledicarboxylate (10.2 g; 97%) was obtained as a thick yellow oil.

出典と根拠

ORDレコード
ord-8b1cfeabcd9342b88f2974a803d4ff71
出典データセット
uspto-grants-1994_07
特許番号
US05329012

反応ノート

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