Potassium Hydroxide → 4-[(Thiochroman-8-YL)oxy]butyric acid

HRID 1729228ノート

反応式

HRID 1729228 の反応式
[S:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH2:13][CH2:14][C:15]([O:17]CC)=[O:16])[CH2:4][CH2:3][CH2:2]1.[OH-].[K+]>CO>[S:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][C:9]=2[O:11][CH2:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 20093602Ethyl 4-[(thiochroman-8-YL)oxy]butyrate

生成物 1

HCID 200936194-[(Thiochroman-8-YL)oxy]butyric acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Under argon and with stirring, 2.25 g (8.02 mmol) of the compound obtained in Step A are dissolved in 30 cm3 of methanol. 4.5 cm3 of a 10% potassium hydroxide solution are added dropwise. After 2 hours at room temperature, the methanol is evaporated off. The residue is acidified very slowly with a 2N hydrochloric acid solution. The resulting precipitate is extracted with CH2Cl2 and dried over MgSO4. 1.94 g of a white solid are recovered.

後処理

  1. customthe methanol is evaporated off
  2. extractionThe resulting precipitate is extracted with CH2Cl2
  3. dry with materialdried over MgSO4
  4. custom1.94 g of a white solid are recovered

出典と根拠

ORDレコード
ord-0bc8b76f10a744dcbbb25f0fa075645a
出典データセット
uspto-grants-1994_07
特許番号
US05332741

反応ノート

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