Bromine → 4-(2',4'-Dichlorophenyl)-5-methylthiazole hydrobromide

HRID 1729272ノート

反応式

HRID 1729272 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9](=O)[CH2:10][CH3:11].[Br:13]Br.[CH:15]([NH2:17])=[S:16]>C(Cl)Cl>[BrH:13].[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:17]=[CH:15][S:16][C:10]=1[CH3:11]

参加物

5

反応物 3

HCID 24408BromineHCID 1234672',4'-DichloropropiophenoneHCID 3005587Methanethioamide

生成物 1

HCID 190124704-(2',4'-Dichlorophenyl)-5-methylthiazole hydrobromide収率 53%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
20 °C

実験手順

To 2',4'-dichloropropiophenone (2.03 g; 0.01 mole) in methylene chloride (20 ml) was added excess bromine in methylene chloride (10 ml) dropwise at 20° C. The methylene chloride layer was washed with sodium sulphite solution and water, separated, dried (MgSO4) and evaporated. The residue was dissolved in ethanol (20 ml) and thioformamide (0.61 g; 0.01 mole) was added and the mixture stirred at 20° C. for 16 hours to give 4-(2',4'-dichlorophenyl)-5-methylthiazole hydrobromide (1.72 g; 53%).

後処理

  1. washThe methylene chloride layer was washed with sodium sulphite solution and water
  2. customseparated
  3. dry with materialdried (MgSO4)
  4. customevaporated
  5. dissolutionThe residue was dissolved in ethanol (20 ml)

出典と根拠

ORDレコード
ord-710cdbd9ed75436bbc898ae53e73aa5c
出典データセット
uspto-grants-1994_07
特許番号
US05332753

反応ノート

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