Isopropanol → HCID 21498784、化合物

HRID 1729989ノート

反応式

HRID 1729989 の反応式
C([N:9]1[CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]=2[CH2:11][CH2:10]1)(=O)C1C=CC=CC=1.CC(O)C>O.OS(O)(=O)=O>[CH2:11]1[CH2:10][NH:9][CH2:18][C:17]2[C:16](=[O:19])[NH:15][C:14]3[CH:20]=[CH:21][CH:22]=[CH:23][C:13]=3[C:12]1=2

参加物

5

反応物 2

HCID 3776IsopropanolHCID 214987793-Benzoyl-2,3,4,6-tetrahydrobenzo[c][2,7]naphthyridin-5(1H)-one

生成物 1

HCID 21498784HCID 21498784、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1118Sulfuric Acid溶媒2 回

実験手順

A solution of 7.7 g (0.025 m) of 3-benzoyl-1,2,3,4-tetrahydrobenzo[c][2,7]naphthyridin-5(6H)-one in 30 ml of water, 10 ml of H2SO4, and 200 ml of 2-propanol was refluxed for 20 hr. After cooling, the solid was filtered and recrystallized from water, mp 292°-295° C. By analysis, this material contains 0.7 mole of H2SO4 per mole of base and was used as is for alkylation.

後処理

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered
  3. customrecrystallized from water, mp 292°-295° C

出典と根拠

ORDレコード
ord-a5f8355d9316499f8b0646878de3c3ca
出典データセット
uspto-grants-1976_11
特許番号
US03991064

反応ノート

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