Ethyl 7-bromoheptanoate → 7-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid

HRID 1730128ノート

反応式

HRID 1730128 の反応式
C([O:4][CH:5]([CH2:14][O:15][C:16]1[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=1)[C:6]#[C:7][CH2:8][NH:9][S:10]([CH3:13])(=[O:12])=[O:11])(=O)C.C(OC(COC1C=CC(F)=CC=1)CCCNS(C)(=O)=O)(=O)C.Br[CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][C:52]([O:54]CC)=[O:53].BrCC#CCCCC(OCC)=O>>[OH:4][CH:5]([CH2:14][O:15][C:16]1[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=1)[C:6]#[C:7][CH2:8][N:9]([CH2:46][CH2:47][CH2:48][CH2:49][CH2:50][CH2:51][C:52]([OH:54])=[O:53])[S:10]([CH3:13])(=[O:11])=[O:12]

参加物

5

反応物 4

HCID 122490Ethyl 7-bromoheptanoateHCID 15174663Ethyl 7-bromohept-5-ynoateHCID 21401584N-[4-acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamideHCID 21401585HCID 21401585、化合物

生成物 1

HCID 214015787-{N-[4-hydroxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamido}heptanoic Acid

実験手順

This compound is prepared by the procedure described in Example 2, Step I, except that N-[4-acetoxy-5-(4-fluorophenoxy)- 2-pentynyl]methanesulfonamide is substituted for the N-[4-acetoxy-5-(4-fluorophenoxy)pentyl]methanesulfonamide and ethyl 7-bromoheptanoate is substituted for ethyl 7-bromo-5-heptynoate. The product is thus ethyl 7-{N-[4 -acetoxy-5-(4-fluorophenoxy)-2-pentynyl]methanesulfonamide} -heptanoate. The subsequent hydrolysis (Example 2, Step J) affords the subject compound.

後処理

  1. customThis compound is prepared by the procedure
  2. customThe subsequent hydrolysis (Example 2, Step J)
  3. customaffords the subject compound

出典と根拠

ORDレコード
ord-3ce367539afe4eb78136e1b9ac559d95
出典データセット
uspto-grants-1976_11
特許番号
US03991106

反応ノート

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