1,4-Dioxane → 2-[2-(2,2-Diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

HRID 1730192

反応式

HRID 1730192 の反応式
OCCN[N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1.[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH2:24])[CH3:20].O1CCOCC1>O>[CH2:19]([O:21][CH:22]([O:25][CH2:26][CH3:27])[CH2:23][NH:24][N:5]1[NH:9][CH:8]=[C:7]([C:10]2[N:11]([CH3:18])[C:12]([N+:15]([O-:17])=[O:16])=[CH:13][N:14]=2)[S:6]1)[CH3:20]

参加物

5

反応物 3

HCID 312751,4-DioxaneHCID 695242,2-DiethoxyethylamineHCID 213908472-[2-(Hydroxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

生成物 1

HCID 213908052-[2-(2,2-Diethoxyethylamino)-5-thiadiazolyl]-1-methyl-5-nitroimidazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture composed of 9.8 g. of 2-(2-chloro-5-thiadiazole)-1-methyl-5-nitroimidazole, (Example 16), 11.0 g. of 2,2-diethoxyethylamine, and 250 ml. of dioxane is stirred and heated on the steam bath for 12 hours. It is then diluted with 500 ml. of cold water, cooled, and the precipitated yellow solid collected and dried. Recrystallization from 50% aqueous ethanol gives the pure compound melting at 154°-155° C.

後処理

  1. temperatureheated on the steam bath for 12 hours
  2. additionIt is then diluted with 500 ml
  3. customthe precipitated yellow solid collected
  4. customdried
  5. customRecrystallization from 50% aqueous ethanol

出典と根拠

ORDレコード
ord-55998eae4d09467f9b4e4fd38f184870
出典データセット
uspto-grants-1976_11
特許番号
US03991200

関連ノート

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