N-Pyridin-4-ylacetamide → 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-acetamidopyridinium iodide

HRID 1730325

反応式

HRID 1730325 の反応式
[I:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][CH3:11])=[C:6]([O:12][CH3:13])[CH:5]=1.[C:14]([NH:17][C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)(=[O:16])[CH3:15]>C(O)C>[I-:1].[CH3:13][O:12][C:6]1[CH:5]=[C:4]([CH2:3][CH2:2][N+:21]2[CH:22]=[CH:23][C:18]([NH:17][C:14](=[O:16])[CH3:15])=[CH:19][CH:20]=2)[CH:9]=[CH:8][C:7]=1[O:10][CH3:11]

参加物

4

反応物 2

HCID 21288N-Pyridin-4-ylacetamideHCID 5970224-(2-Iodoethyl)-1,2-dimethoxybenzene

生成物 1

HCID 214132591-[2-(3,4-Dimethoxyphenyl)ethyl]-4-acetamidopyridinium iodide収率 67.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-(2-Iodoethyl)-3,4-dimethoxybenzene (29.3 g.) and 4-acetamidopyridine (14.0 g.) in absolute ethanol (100 ml.) were refluxed for 2.5 hours. The resulting crystalline material was collected and recrystallised from ethanol to give the title compound (29.1 g.), m.p. 201°-202°C. (Found: C, 47.9; H, 4.9; N, 6.3; C17H21IN2O3 requires C, 47.7; H, 4.9; N, 6.5%).

後処理

  1. customThe resulting crystalline material was collected
  2. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-3b203e8f655b45ceb642ad9772d2a559
出典データセット
uspto-grants-1976_11
特許番号
US03992389

関連ノート

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