Potassium Carbonate → HCID 21430607、化合物

HRID 1730333ノート

反応式

HRID 1730333 の反応式
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]=1.[C:13]([NH:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C>[CH2:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][N:25]2[CH2:26][CH2:27][CH:22]([NH:21][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:23][CH2:24]2)=[CH:5]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 121780961-bromo-2-(3-indenyl)ethane

生成物 1

HCID 21430607HCID 21430607、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

3-(2-Bromoethyl)indene (1.12 g.), 4-benzamidopiperidine (1.02 g.) and potassium carbonate (1.38 g.) were heated under reflux in isopropanol (25 ml.) for 24 hours. The mixture was filtered and the filtrate was evaporated. Trituration of the residue with ether gave a solid which was recrystallised twice from aqueous ethanol to provide the title compound, m.p. 148°-149° C. (Found: C, 79.7; H, 7.6; N, 8.0. C23H26N2O requires C, 79.7; H, 7.6; N, 8.1%).

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customTrituration of the residue with ether gave a solid which
  4. customwas recrystallised twice from aqueous ethanol

出典と根拠

ORDレコード
ord-b63d9eb282644f0184e64824a36879b4
出典データセット
uspto-grants-1976_11
特許番号
US03992389

反応ノート

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