Potassium Carbonate → 1-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine

HRID 1730347ノート

反応式

HRID 1730347 の反応式
[C:1]([NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[Cl:22][C:23]1[CH:24]=[C:25]([CH2:30][CH2:31]Br)[CH:26]=[CH:27][C:28]=1[Cl:29]>>[Cl:22][C:23]1[CH:24]=[C:25]([CH2:30][CH2:31][N:13]2[CH2:14][CH2:15][CH:10]([NH:9][C:1](=[O:8])[C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:11][CH2:12]2)[CH:26]=[CH:27][C:28]=1[Cl:29]

参加物

4

反応物 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 151493894-(2-Bromoethyl)-1,2-dichlorobenzene

生成物 1

HCID 214132531-[2-(3,4-Dichlorophenyl)ethyl]-4-benzamidopiperidine収率 94.2%

反応条件

温度
100 °C

実験手順

4-Benzamidopiperidine (204 mg.) and anhydrous potassium carbonate (138 mg.)were intimately ground together and added to 2-(3,4-dichlorophenyl)ethyl bromide (254 mg.). The resulting paste was heated at 100° C for 2 hours to give a hard solid. This was broken up, washed well with water andether and dried to give the title compound (355 mg.). Recrystallisation from ethanolic hydrogen chloride and ether gave the hydrochloride (237 mg.), m.p. 286.0° C. (Found: C, 58.2; H, 5.8; N, 6.8. C20H22Cl2N2O.HCl requires C, 58.05; H, 5.6; N, 6.8%).

後処理

  1. customto give a hard solid
  2. washwashed well with water andether
  3. customdried

出典と根拠

ORDレコード
ord-dc49b45bbee1484b94c8efa1040cbaa0
出典データセット
uspto-grants-1976_11
特許番号
US03992389

反応ノート

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