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Ethyl orthoformate → 5-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | (2-Methyl-1,3-dioxolan-2-yl)methanamine | HCID 12434663 | — |
| 反応物 | 2-[(2-Chlorophenyl)methyl]aniline | HCID 13426664 | — |
| 触媒 | Titanium Tetrachloride | HCID 24193 | — |
| 生成物 | 5-Methyl-1-[alpha-(o-chlorophenyl)-o-tolyl]imidazole | HCID 21497387 | — |
反応手順
In the manner given in Example 3, α-(o-chlorophenyl)-o-toluidine is reacted with triethyl orthoformate, the resulting oil is heated with 2-methyl-2-(aminomethyl)-1,3-dioxolane, and the resulting product treated with titanium tetrachloride to give 5-methyl-1-[α-(o-chlorophenyl)-o-tolyl]imidazole.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03992400 |
| 出典データセット | uspto-grants-1976_11 |
| ORD ID | ord-cc13805fd1e8428d87430670069f7e86 |
| 出典メモ | uspto-grants-1976_11 |