P-Nitrobenzotrifluoride → 4-(Trifluoromethyl)aniline

HRID 1730725

反応式

HRID 1730725 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pt]=O>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 9821P-NitrobenzotrifluorideHCID 178418361HCID 178418361、化合物3 回

生成物 1

HCID 99644-(Trifluoromethyl)aniline収率 94%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

160 Parts of p-nitrobenzotrifluoride is dissolved in 500 parts of ethanol and 1 part platinum oxide catalyst is added. The mixture is placed in a pressure vessel and hydrogen is added at a temperature of 30° C and a pressure of 13.6 atmospheres. The hydrogen pressure is increased to 34 atmospheres during the course of the reaction, which continues until the hydrogen uptake ceases. The excess hydrogen is removed from the reaction vessel under reduced pressure and the catalyst is removed from the mixture by filtration. The solvent is removed from the filtrate under reduced pressure to give 127 parts (94% yield) of p-aminobenzotrifluoride.

後処理

  1. additionis added
  2. customThe mixture is placed in a pressure vessel
  3. customThe excess hydrogen is removed from the reaction vessel under reduced pressure
  4. customthe catalyst is removed from the mixture by filtration
  5. customThe solvent is removed from the filtrate under reduced pressure

出典と根拠

ORDレコード
ord-e5ee7aa95bfb4b2e810bd372dbe797f9
出典データセット
uspto-grants-1976_11
特許番号
US03993704

関連ノート

読み込み中…