Potassium Carbonate → alpha-[3-Chloro-4-(3-hydroxypyrrolidino)-phenyl]-propionic acid

反応式

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:4][C:3]=1[Cl:13].Cl[CH2:15][CH:16]([OH:20])[CH2:17][CH2:18]Cl.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Cl:13][C:3]1[CH:4]=[C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])[CH:6]=[CH:7][C:2]=1[N:1]1[CH2:18][CH2:17][CH:16]([OH:20])[CH2:15]1

参加物

実験手順

To the solution of 2.0 g of α-(4-amino-3-chlorophenyl)-propionic acid in 20 ml of ethanol, 1.4 g of 1,4-dichloro-2-butanol are added, followed by 4 g of potassium carbonate while stirring. The mixture is stirred for 4 hours at the steam cone and evaporated under reduced pressure. The residue is taken up in water, the solution acidified with N hydrochloric acid to a pH of 5.5 and extracted with diethyl ether. The extract is dried, filtered and evaporated, to yield the α-[3-chloro-4-(3-hydroxypyrrolidino)-phenyl]-propionic acid of the formula ##SPC9##