Benzene → N-cyclohexyl-2,5-dimethylfuran-3-hydroxamic acid

HRID 1730807

反応式

HRID 1730807 の反応式
Cl.[CH:2]1([NH:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C1C=CC=CC=1.[CH3:16][C:17]1[O:18][C:19]([CH3:25])=[CH:20][C:21]=1[C:22](Cl)=[O:23]>C(N(CC)CC)C>[CH:2]1([N:8]([C:22]([C:21]2[CH:20]=[C:19]([CH3:25])[O:18][C:17]=2[CH3:16])=[O:23])[OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

5

反応物 3

HCID 241BenzeneHCID 27348042,5-Dimethyl-3-furoyl ChlorideHCID 3084432N-Cyclohexylhydroxylamine hydrochloride

生成物 1

HCID 21496538N-cyclohexyl-2,5-dimethylfuran-3-hydroxamic acid

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

16.6 Parts of N-cyclohexylhydroxylamine hydrochloride is added to 300 parts of benzene; 20.2 parts of triethylamine is then introduced into the mixture. After stirring the mixture for 1 hour at room temperature, 15.9 parts of 2,5-dimethylfuran-3-carboxylic chloride is dripped in. The mixture is then stirred for a further hour and the precipitate is suction filtered, washed with water and then with petroleum ether, and dried. There is obtained 18.2 parts of N-cyclohexyl-2,5-dimethylfuran- 3-hydroxamic acid; m.p.: 135° - 137° C. ##SPC7##

後処理

  1. stirringThe mixture is then stirred for a further hour
  2. filtrationfiltered
  3. washwashed with water
  4. dry with materialwith petroleum ether, and dried

出典と根拠

ORDレコード
ord-c587569a1aa0400a892fffe83ac76d21
出典データセット
uspto-grants-1976_11
特許番号
US03993772

関連ノート

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