Water → N-cyclopentyl-2,5-dimethylfuran-3-hydroxamic acid

HRID 1730808

反応式

HRID 1730808 の反応式
Cl.[CH:2]1([NH:7][OH:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.C(=O)([O-])O.[Na+].O.[CH3:15][C:16]1[O:17][C:18]([CH3:24])=[CH:19][C:20]=1[C:21](Cl)=[O:22]>ClCCl>[CH:2]1([N:7]([C:21]([C:20]2[CH:19]=[C:18]([CH3:24])[O:17][C:16]=2[CH3:15])=[O:22])[OH:8])[CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

6

反応物 4

HCID 962WaterHCID 516892Sodium BicarbonateHCID 27348042,5-Dimethyl-3-furoyl ChlorideHCID 21496528N-cyclopentylhydroxylamine hydrochloride

生成物 1

HCID 21496542N-cyclopentyl-2,5-dimethylfuran-3-hydroxamic acid

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

27.5 Parts of N-cyclopentylhydroxylamine hydrochloride is dissolved in 200 parts of dichloromethane; a solution of 33.6 parts of sodium hydrogen carbonate in 300 parts of water is then added. At room temperature and while stirring thoroughly, 31.8 parts of 2,5-dimethylfuran-3-carboxylic chloride is dripped into this mixture. After stirring the mixture for 1 hour the organic phase is separated, dried over anhydrous sodium sulfate and evaporated. The oil which remains soon solidifies and the crystals obtained are stirred with petroleum ether, suction filtered and dried. There is obtained 14.3 parts of N-cyclopentyl-2,5-dimethylfuran-3-hydroxamic acid having a melting point of from 107° to 109° C. ##SPC9##

後処理

  1. stirringAfter stirring the mixture for 1 hour the organic phase
  2. customis separated
  3. dry with materialdried over anhydrous sodium sulfate
  4. customevaporated
  5. customthe crystals obtained
  6. filtrationfiltered
  7. customdried

出典と根拠

ORDレコード
ord-560fb24bd6e944b08c3dccc8283e414f
出典データセット
uspto-grants-1976_11
特許番号
US03993772

関連ノート

読み込み中…