Hydrochloric Acid → 3,4-Methylenedioxyphenylalanyl chloride hydrochloride

反応式

[CH2:1]1[O:15][C:14]2[CH:13]=[CH:12][C:5]([CH2:6][C@@H:7]([C:9](O)=[O:10])[NH2:8])=[CH:4][C:3]=2[O:2]1.Cl.P(Cl)(Cl)(Cl)(Cl)[Cl:18].Cl.C1(NCC([Cl:34])=O)C=CC=CC=1>>[ClH:18].[CH2:1]1[O:15][C:14]2[CH:13]=[CH:12][C:5]([CH2:6][C@@H:7]([C:9]([Cl:34])=[O:10])[NH2:8])=[CH:4][C:3]=2[O:2]1

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 24819Phosphorus pentachloride

HCID 12918717(S)-2-Amino-3-(benzo[D][1,3]dioxol-5-YL)propanoic acid

HCID 13140662N-Phenylglycyl chloride--hydrogen chloride (1/1)

生成物 1

HCID 867342163,4-Methylenedioxyphenylalanyl chloride hydrochloride

実験手順

The compound 3,4-methylenedioxyphenylalanine, Ber., 59, 2952 (1926), is treated with hydrogen chloride and phosphorous pentachloride in accordance with the procedure described by Hartcastle et al., J. Org. Chem. 31, 897 (1966) for the preparation of phenylglycyl chloride hydrochloride to yield 3,4-methylenedioxyphenylalanyl chloride hydrochloride.

出典と根拠

ORDレコード: ord-1c9eaf80b3db4387a11fdc747f27a4ba
出典データセット: uspto-grants-1976_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03994877

反応ノート

読み込み中…