Hydrochloric Acid → 2,3-Methylenedioxyphenylalanyl chloride hydrochloride

反応式

[CH2:1]1[O:15][C:14]2[C:3](=[C:4]([CH:11]=[CH:12][CH:13]=2)[CH2:5][C@@H:6]([C:8](O)=[O:9])[NH2:7])[O:2]1.Cl.P(Cl)(Cl)(Cl)(Cl)[Cl:18].Cl.C1(NCC([Cl:34])=O)C=CC=CC=1>>[ClH:18].[CH2:1]1[O:15][C:14]2[C:3](=[C:4]([CH:11]=[CH:12][CH:13]=2)[CH2:5][C@@H:6]([C:8]([Cl:34])=[O:9])[NH2:7])[O:2]1

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 24819Phosphorus pentachloride

HCID 13140662N-Phenylglycyl chloride--hydrogen chloride (1/1)

HCID 54422979(s)-2-Amino-3-(benzo[d][1,3]dioxol-4-yl)propanoic acid

生成物 1

HCID 867342172,3-Methylenedioxyphenylalanyl chloride hydrochloride

実験手順

The compound 2,3-methylenedioxyphenylalanine, is treated with hydrogen chloride and phosphorous pentachloride in accordance with the procedure described by Hartcastle et al., J. Org. Chem., 31, 897 (1966) for the preparation of phenylglycyl chloride hydrochloride to yield 2,3-methylenedioxyphenylalanyl chloride hydrochloride.