Sodium Bromide → HCID 100834、化合物

HRID 1730874ノート

反応式

HRID 1730874 の反応式
S(O[CH2:12][CH2:13][CH2:14][CH:15]=[CH:16][C:17]#[C:18][CH2:19][CH3:20])(C1C=CC(C)=CC=1)(=O)=O.[Br-:21].[Na+]>CN(C)C=O>[Br:21][CH2:12][CH2:13][CH2:14][CH:15]=[CH:16][C:17]#[C:18][CH2:19][CH3:20]

参加物

4

反応物 2

HCID 253881Sodium BromideHCID 53748711HCID 53748711、化合物

生成物 1

HCID 100834HCID 100834、化合物収率 84%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 42.7 g. of 1-tosyloxynon-4-en-6-yne (0.14 moles) in 150 ml. of anhydrous dimethylformamide is added 18.7 g. of sodium bromide (0.16 moles) and the mixture is heated at 75° for 2 hour and then allowed to stir overnight at room temperature. The reaction mixture is then diluted with 200 ml. of ice water and extracted with pentane. The pentane extract is washed with water and dried over sodium sulfate. Evaporation of solvent in vacuo and distillation of the residue oil gave 24.3 g. of 1-bromonon-4-en-6-yne (84% yield) b.p. 52°-55° at 0.15 mm.

後処理

  1. additionThe reaction mixture is then diluted with 200 ml
  2. extractionof ice water and extracted with pentane
  3. extractionThe pentane extract
  4. washis washed with water
  5. dry with materialdried over sodium sulfate
  6. customEvaporation of solvent
  7. distillationin vacuo and distillation of the residue oil
  8. customgave 24.3 g

出典と根拠

ORDレコード
ord-f67d03a9bef14119b61704a79806ca31
出典データセット
uspto-grants-1976_11
特許番号
US03994896

反応ノート

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