Diphenic anhydride → 2'-[[[3-(4-Phenyl-1-piperidinyl)propyl]amino]-carbonyl][1,1'-biphenyl]-2-carboxylic acid

HRID 1731132

反応式

HRID 1731132 の反応式
Cl.[C:2]1([CH:8]2[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][CH2:16][NH2:17])[CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]12[C:25]3=[CH:26][CH:27]=[CH:28][CH:29]=[C:24]3[C:23](=[O:30])[O:22][C:20](=[O:21])[C:19]1=[CH:31][CH:32]=[CH:33][CH:34]=2>C1(C)C=CC=CC=1>[C:2]1([CH:8]2[CH2:9][CH2:10][N:11]([CH2:14][CH2:15][CH2:16][NH:17][C:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=3[C:18]3[C:19]([C:20]([OH:22])=[O:21])=[CH:31][CH:32]=[CH:33][CH:34]=3)=[O:30])[CH2:12][CH2:13]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 72794Diphenic anhydrideHCID 1317105484-Phenyl-1-piperidinepropanamine, hydrochloride

生成物 1

HCID 214951832'-[[[3-(4-Phenyl-1-piperidinyl)propyl]amino]-carbonyl][1,1'-biphenyl]-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

4-Phenyl-1-piperidinepropanamine, hydrochloride (prepared in part A) (16.33 g, 53.5 mM) and diphenic anhydride (12.0 g, 53.5 mM) are refluxed in toluene for 2 hours. The mixture is allowed to stand overnight at room temperature during which time product crystallizes out. The crystals are filtered off, washed with toluene, recrystallized from ethanol, and dried at 80° to give the title compound.

後処理

  1. customcrystallizes out
  2. filtrationThe crystals are filtered off
  3. washwashed with toluene
  4. customrecrystallized from ethanol
  5. customdried at 80°

出典と根拠

ORDレコード
ord-69828a33aa7f4856889aa9212ce3fcc1
出典データセット
uspto-grants-1976_11
特許番号
US03995045

関連ノート

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