Hydrochloric Acid → 2-(beta-[2-Dimethylaminoethyl]phenethyl)benzoic acid ethyl ester

HRID 1731202ノート

反応式

HRID 1731202 の反応式
[CH3:1][N:2]([CH3:22])[CH2:3][CH2:4][CH:5]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:6][C:7]1[CH:15]=[CH:14][CH:13]=[CH:12][C:8]=1[C:9]([OH:11])=[O:10].Cl.[CH2:24](O)[CH3:25]>>[CH2:24]([O:10][C:9](=[O:11])[C:8]1[CH:12]=[CH:13][CH:14]=[CH:15][C:7]=1[CH2:6][CH:5]([CH2:4][CH2:3][N:2]([CH3:1])[CH3:22])[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH3:25]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 20359294HCID 20359294、化合物

生成物 1

HCID 539227562-(beta-[2-Dimethylaminoethyl]phenethyl)benzoic acid ethyl ester

実験手順

A solution of 29.7 g. (0.1 mole) of 2-(β-[2-dimethylaminoethyl]phenethyl)benzoic acid in 200 ml. of ethanol is saturated with gaseous hydrochloride, and the resulting mixture is refluxed for 18 hours. The solvent is removed in vacuo and the residue is partitioned between ether and 2N sodium hydroxide. The ether extract is dried and evaporated in vacuo to give 2-(β-[2-dimethylaminoethyl]phenethyl)benzoic acid ethyl ester.

後処理

  1. temperaturethe resulting mixture is refluxed for 18 hours
  2. customThe solvent is removed in vacuo
  3. customthe residue is partitioned between ether and 2N sodium hydroxide
  4. extractionThe ether extract
  5. customis dried
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-c77498e59f0b48afa89c4ac5a2b92de3
出典データセット
uspto-grants-1976_11
特許番号
US03994961

反応ノート

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