Hydrochloric Acid → Z-Thr(But)-Ser(But)-OMe

HRID 1731231ノート

反応式

HRID 1731231 の反応式
[NH:1]([C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])[C@H:2]([C:10]([O:12]N1C(=O)CCC1=O)=O)[C@@H:3]([CH3:9])[O:4][C:5]([CH3:8])([CH3:7])[CH3:6].[NH2:30][C@H:31]([C:38]([O:40][CH3:41])=[O:39])[CH2:32][O:33][C:34]([CH3:37])([CH3:36])[CH3:35].Cl.C(OCC)(=O)C>C(N(CC)CC)C>[NH:1]([C:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:21])[C@H:2]([C:10]([NH:30][C@H:31]([C:38]([O:40][CH3:41])=[O:39])[CH2:32][O:33][C:34]([CH3:37])([CH3:36])[CH3:35])=[O:12])[C@@H:3]([CH3:9])[O:4][C:5]([CH3:6])([CH3:7])[CH3:8]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 7018830(S)-Methyl 2-amino-3-(tert-butoxy)propanoateHCID 13503275Z-Thr(tBu)-OSU

生成物 1

HCID 131710554Z-Thr(But)-Ser(But)-OMe

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

反応条件

温度
20 °C

実験手順

16.25 g of Z-Thr(But)-OSu and 8.47 g of H-Ser(But)-OMe. HCl are added to 200 ml of ethyl acetate, 5.6 ml of triethylamine are added at 0°C and the solution is stirred for 15 hours at 20°C and washed with 1 N citric acid, 1 N sodium bicarbonate and water. After drying over sodium sulphate, the solution is evaporated, whereupon the product, which is pure according to thin layer chromatography, is obtained as an oil.

後処理

  1. additionare added at 0°C
  2. washwashed with 1 N citric acid, 1 N sodium bicarbonate and water
  3. dry with materialAfter drying over sodium sulphate
  4. customthe solution is evaporated, whereupon the product, which
  5. customis obtained as an oil

出典と根拠

ORDレコード
ord-be6a612873934733895b42cd6419d82f
出典データセット
uspto-grants-1976_11
特許番号
US03994871

反応ノート

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