Hydrochloric Acid → 5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid

HRID 1731270

反応式

HRID 1731270 の反応式
[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[C:8]([O:10]CC)=[O:9].[OH-].[K+].C(O)C.Cl>O>[Cl:1][C:2]1[N:6]([CH3:7])[N:5]=[CH:4][C:3]=1[C:8]([OH:10])=[O:9]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 702EthanolHCID 14797Potassium HydroxideHCID 2758821Ethyl 5-Chloro-1-methyl-1H-pyrazole-4-carboxylate

生成物 1

HCID 27357745-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid, ethyl ester (13 grams, 0.07 mole) and potassium hydroxide (7.8 grams, 0.14 mole) were combined in 75 ml. of ethanol and refluxed for six hours. The solution was cooled, poured over water, acidified with concentrated hydrochloric acid, and the precipitated solid collected, dried, and recrystallized from water. The resulting 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid was obtained in the amount of 5.4 grams and melted at 195°-197° C.

後処理

  1. temperatureThe solution was cooled
  2. customthe precipitated solid collected
  3. customdried
  4. customrecrystallized from water

出典と根拠

ORDレコード
ord-4250428618d14b3b878acef53985b60c
出典データセット
uspto-grants-1986_11
特許番号
US04620865

関連ノート

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