Aniline → ethyl 7-anilino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate

HRID 1731295

反応式

HRID 1731295 の反応式
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12.[NH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[NH:16]([C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]2[CH:13]=[N:14][NH:15][C:3]=12)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

3

反応物 2

HCID 6115AnilineHCID 20038759Ethyl 7-chloro-1H-pyrazolo[4,3-B]pyridine-6-carboxylate

生成物 1

HCID 20228774ethyl 7-anilino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate収率 67%

実験手順

Ethyl 7-chloro-1H-pyrazolo[4,3-b]-pyridine-6-carboxylate (370 mg, 1.6 mmol) was dissolved in aniline (3 ml) and stirred overnight. The resulting mixture was triturated with 60°-80° petrol, and the precipitated solid was collected and dissolved in aqueous ethanol. The solution was adjusted to pH 8 with saturated sodium hydrogen carbonate solution, and the precipitated solid was collected to give the title compound (310 mg, 67%) m.p. 164°-165° C.

後処理

  1. customThe resulting mixture was triturated with 60°-80° petrol
  2. customthe precipitated solid was collected
  3. dissolutiondissolved in aqueous ethanol
  4. customthe precipitated solid was collected

出典と根拠

ORDレコード
ord-2a817258bec941b081240a6e8f17ecf2
出典データセット
uspto-grants-1986_11
特許番号
US04621089

関連ノート

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