Choline → HCID 20228180、化合物

HRID 1731661

反応式

HRID 1731661 の反応式
C(O[CH2:4][CH2:5][C:6]#[N:7])C.C(O)C.[NH:11]([C:13]1[S:14][C:15]2[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=2[N:17]=1)[NH2:12].OCC[N+](C)(C)C>CO>[NH2:7][C:6]1[CH2:5][CH2:4][N:11]([C:13]2[S:14][C:15]3[CH:21]=[CH:20][CH:19]=[CH:18][C:16]=3[N:17]=2)[N:12]=1

参加物

6

反応物 4

HCID 305CholineHCID 702EthanolHCID 119882-Benzothiazolinone, hydrazoneHCID 16501Propanenitrile, 3-ethoxy-

生成物 1

HCID 20228180HCID 20228180、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 5.0 g. of β-ethoxypropionitrile, 100 ml. of absolute ethanol, 8.25 g. of 2-hydrazinobenzothiazole and 2.5 g. of 50% w/v choline in methanol is refluxed on a steam bath for 16 hours, then the solvent is removed in vacuo. Water is added and the solid is collected by filtration. The solid is recrystalized twice from ethanol to give 5.75 g. of the product of the Example as grey prisms, m.p. 231.5°-235° C.

後処理

  1. additionA mixture of 5.0 g
  2. temperatureis refluxed on a steam bath for 16 hours
  3. customthe solvent is removed in vacuo
  4. additionWater is added
  5. filtrationthe solid is collected by filtration
  6. customThe solid is recrystalized twice from ethanol
  7. customto give 5.75 g

出典と根拠

ORDレコード
ord-96eb4ec0f63c4844ba66b37c8d009237
出典データセット
uspto-grants-1986_11
特許番号
US04622401

関連ノート

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