Diethylamine → N,N-diethyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

HRID 1731937ノート

反応式

HRID 1731937 の反応式
Cl[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.Cl[C:17]1[C:18]2[N:19](C=NN=2)[C:20]2C(N=1)=CC=C[CH:21]=2.C(NCC)C.C(NCCC)CC>>[CH2:18]([N:19]([CH2:20][CH3:21])[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:17]

参加物

5

反応物 4

HCID 8021DiethylamineHCID 8902DipropylamineHCID 11261184-Chloro[1,2,4]triazolo[4,3-a]quinoxalineHCID 27686434-Chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline

生成物 1

HCID 899504N,N-diethyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine収率 54%

実験手順

This compound was prepared by the method of Example 11, utilizing 4-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 3) as starting material in place of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 2) and diethylamine as reagent in place of di-n-propylamine. The crude product obtained was recrystallized from chloroform and then from cyclohexane to afford 7.2 g. (54% yield) of pure 4-diethylamino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 123°-5° C.

後処理

  1. customThe crude product obtained
  2. customwas recrystallized from chloroform
  3. customfrom cyclohexane to afford 7.2 g

出典と根拠

ORDレコード
ord-71cebf7c53bb4a4f94011102eb89c88d
出典データセット
uspto-grants-1986_11
特許番号
US04623725

反応ノート

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