化工社化工社 化学情報印刷レポート · 研究参考用
Mercaptoethanesulfonic acid → Mafosfamide Sodium Salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Mercaptoethanesulfonic acid | HCID 598 | — |
| 反応物 | 4-Hydroxycyclophosphamide | HCID 99735 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Mafosfamide Sodium Salt | HCID 104746 | — |
反応手順
0.8 g (3.0 mmol) of 4-hydroxycyclophosphamide in 3 ml of water were mixed with 420 mg (3.0 mmol) of 2-mercaptoethanesulphonic acid, with ice water cooling. After 1 hour, the mixture was concentrated under high vacuum and was crystallised.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04623742 |
| 出典データセット | uspto-grants-1986_11 |
| ORD ID | ord-619ed1eb67204fd4b7bf039408ffcadd |
| 出典メモ | uspto-grants-1986_11 |