Methyl isothiocyanate → 2-Amino-5-(methyl-thiocarbamoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine
反応式
[NH2:1][C:2]1[S:3][C:4]2[CH2:5][NH:6][CH2:7][CH2:8][C:9]=2[N:10]=1.[CH3:11][N:12]=[C:13]=[S:14]>CN(C)C=O>[NH2:1][C:2]1[S:3][C:4]2[CH2:5][N:6]([C:13](=[S:14])[NH:12][CH3:11])[CH2:7][CH2:8][C:9]=2[N:10]=1参加物
4
実験手順
1.55 G (10 mmol) of 2-amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine was dissolved in 25 ml of dimethylformamide and the solution was cooled in an ice-water bath. 0.88 g (12 mmol) of methyl isothiocyanate was then added. After 71/2 hours the solvent was removed by evaporation and the residue (about 2.2 g) was crystallized from acetonitrile. 1.25 g (55% yield) of the pure title compound (m.p. 188°-190° C. with decomposition) were obtained.
後処理
- temperaturethe solution was cooled in an ice-water bath
- customAfter 71/2 hours the solvent was removed by evaporation
- customthe residue (about 2.2 g) was crystallized from acetonitrile
出典と根拠
- ORDレコード
- ord-f32c17a8c4d746dab4300c85204a2adb
- 出典データセット
- uspto-grants-1986_11
- 特許番号
- US04624956
反応ノート
読み込み中…