Propylene Oxide → 1-[4-(3-Fluorophenoxy)phenoxy]propan-2-ol

HRID 1732157ノート

反応式

HRID 1732157 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.[CH2:16]1[O:19][CH:17]1[CH3:18].C(N(CC)CC)C>C(OCC)C>[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH2:16][CH:17]([OH:19])[CH3:18])=[CH:8][CH:7]=1

参加物

5

反応物 3

HCID 6378Propylene OxideHCID 8471TriethylamineHCID 109216164-(3-Fluorophenoxy)phenol

生成物 1

HCID 137531881-[4-(3-Fluorophenoxy)phenoxy]propan-2-ol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
90 °C

実験手順

A mixture of 6.13 g of p-(m-fluorophenoxy)phenol, 2.79 g of propylene oxide and 0.12 g of triethylamine is stirred at 90° C. for 18 hours. The cooled mixture is subsequently diluted with 100 ml of diethyl ether and washed successively twice with 50 ml of 2N hydrochloric acid each time, three times with 50 ml of 2N sodium hydroxide each time, with 50 ml of water and with 50 ml of saturated sodium chloride solution. After drying over anhydrous sodium sulfate and evaporation there is obtained 1-[p-(m-fluorophenoxy)phenoxy]-2-propanol of melting point 37°-39° C.

後処理

  1. washwashed successively twice with 50 ml of 2N hydrochloric acid each time, three times with 50 ml of 2N sodium hydroxide each time
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. customevaporation there

出典と根拠

ORDレコード
ord-7d78d94e419c4f73b0189b78574d9a05
出典データセット
uspto-grants-1986_11
特許番号
US04625048

反応ノート

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