Phosphorus oxychloride → 2-Chloro-6-fluoroquinoline

HRID 1732187ノート

反応式

HRID 1732187 の反応式
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=O)[CH:6]=[CH:5]2.P(Cl)(Cl)([Cl:15])=O>>[Cl:15][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([F:1])[CH:3]=2)[N:8]=1

参加物

3

反応物 2

HCID 24813Phosphorus oxychlorideHCID 98340436-Fluoro-1,2-dihydroquinolin-2-one

生成物 1

HCID 150594332-Chloro-6-fluoroquinoline

実験手順

A mixture of the so-prepared 6-fluorocarbostyril (2.9 gm, 0.018 mole) and 30.0 ml of phosphorous oxychloride was refluxed for 1.5 hr. Most of the excess phosphorous oxychloride was then distilled off under aspirator vacuum and the residue poured over crushed ice. The reaction mixture was made nearly neutral with 50% sodium hydroxide. The crude solid product was collected by filtration, taken up in

後処理

  1. temperaturewas refluxed for 1.5 hr
  2. distillationMost of the excess phosphorous oxychloride was then distilled off under aspirator vacuum
  3. additionthe residue poured
  4. customover crushed ice
  5. filtrationThe crude solid product was collected by filtration

出典と根拠

ORDレコード
ord-0793f36da021490f8ff5dd1a0618968b
出典データセット
uspto-grants-1980_12
特許番号
US04236912

反応ノート

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