Hydrochloric Acid → 2-(2-Amino-4-thiazolyl)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)imino acetic acid, hydrochloride salt
反応式
[ClH:1].[C:2]1([CH:8]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[O:9][C:10]([C:12]([CH3:28])([O:14][N:15]=[C:16]([C:20]2[N:21]=[C:22]([NH:25]C=O)[S:23][CH:24]=2)[C:17]([OH:19])=[O:18])[CH3:13])=[O:11])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO>[ClH:1].[NH2:25][C:22]1[S:23][CH:24]=[C:20]([C:16](=[N:15][O:14][C:12]([C:10]([O:9][CH:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[O:11])([CH3:28])[CH3:13])[C:17]([OH:19])=[O:18])[N:21]=1参加物
4
実験手順
Concentrated hydrochloric acid (403 μl., 4.84 mmol.) is added to a suspension of the product from part (d) (1.7 g., 3.64 mmol.) in dry methanol. The suspended material dissolves immediately and the reaction mixture is stirred for four hours. The solvent is removed under reduced pressure yielding as a residue 2-(2-amino-4-thiazolyl)-2-(1-diphenylmethoxycarbonyl-1-methylethoxy)imino acetic acid, hydrochloride salt: NMR (CDCl3 -CD3OD) δ 1.70 (s,6H,CH3), 6.93 (s, 1H, thiazole H), 7.02 (s, 1H, CHO), 7.33 (s, 10H, aromatic H).