2-Aminothiazole → HCID 57266412、化合物

HRID 1732304ノート

反応式

HRID 1732304 の反応式
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH2:7]([O:10][C:11]([C:13]#[C:14][C:15](OCCC)=[O:16])=[O:12])[CH2:8][CH3:9]>C(O)C>[CH2:7]([O:10][C:11]([C:13]1[N:6]2[CH:5]=[CH:4][S:3][C:2]2=[N:1][C:15](=[O:16])[CH:14]=1)=[O:12])[CH2:8][CH3:9]

参加物

4

反応物 2

HCID 21552-AminothiazoleHCID 305766dipropyl but-2-ynedioate

生成物 1

HCID 57266412HCID 57266412、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

10 g of 2-aminothiazole are dissolved in 150 ml of absolute ethanol and 19.8 g of acetylene dicarboxylic acid di-n-propyl ester are added to the resulting solution. The mixture is heated to 50° to 60° C. for 10 minutes. After standing overnight at room temperature the precipitate is filtered off, washed with ether and dried in vacuo. 7H-thiazolo-[3,2-a]-pyrimidin-7-one-5-carboxylic acid n-propyl ester melting at 154°-156° C. with decomposition is thus obtained in a yield of 14.5 g (61% of the theoretical).

後処理

  1. temperatureThe mixture is heated to 50° to 60° C. for 10 minutes
  2. filtrationthe precipitate is filtered off
  3. washwashed with ether
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-307cbcc4399b4abe93eab79083254447
出典データセット
uspto-grants-1980_12
特許番号
US04237136

反応ノート

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