Imidazole → HCID 12786233、化合物

HRID 1732461ノート

反応式

HRID 1732461 の反応式
[OH:1][C:2]([CH3:10])([CH2:6][CH2:7][CH:8]=[CH2:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.CN(C)C=O.[CH3:21][Si:22]([CH3:26])([CH3:25])OCl>O>[CH3:10][C:2]([O:1][Si:22]([CH3:26])([CH3:25])[CH3:21])([CH2:6][CH2:7][CH:8]=[CH2:9])[CH2:3][C:4]#[CH:5]

参加物

6

反応物 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 205650044-Hydroxy-4-methyl-oct-1-yn-7-eneHCID 20565034HCID 20565034、化合物

生成物 1

HCID 12786233HCID 12786233、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 50 g. of 4-hydroxy-4-methyl-oct-1-yn-7-ene and 61.3 g. of imidazole in 100 ml. of dimethylformamide at 0° C., is added, with stirring, 49.1 g. of trimethylsilyloxy chloride. The mixture is stirred at room temperature overnight and poured into petroleum ether and water. The organic layer is washed with water and saturated sodium bicarbonate solution and dried over magnesium sulfate. The solvent is removed and the residue distilled (74°-78° C., 1.5 mm.) to give the product as a colorless liquid.

後処理

  1. additionTo a mixture of 50 g
  2. stirringThe mixture is stirred at room temperature overnight
  3. washThe organic layer is washed with water and saturated sodium bicarbonate solution
  4. dry with materialdried over magnesium sulfate
  5. customThe solvent is removed
  6. distillationthe residue distilled (74°-78° C., 1.5 mm.)

出典と根拠

ORDレコード
ord-7dea9a1e3cd646a1b8ff6344510251ca
出典データセット
uspto-grants-1980_12
特許番号
US04237307

反応ノート

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