4-(((2-Aminoethyl)thio)methyl)-5-methylimidazole → 1H-PYRROL-2-AMINE, N-[2-[[(5-METHYL-1H-IMIDAZOL-
反応式
CS([C:4]1[NH:5][CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10])=O.[CH3:12][C:13]1[NH:17][CH:16]=[N:15][C:14]=1[CH2:18][S:19][CH2:20][CH2:21][NH2:22]>CO>[CH3:12][C:13]1[NH:17][CH:16]=[N:15][C:14]=1[CH2:18][S:19][CH2:20][CH2:21][NH:22][C:4]1[NH:5][CH:6]=[CH:7][C:8]=1[N+:9]([O-:11])=[O:10]参加物
4
実験手順
A solution of 2-methylsulphinyl-3-nitropyrrole (2g, 0.01 mol) and 2-(5-methyl-4-imidazolylmethylthio)-ethylamine (2g, 0.01 mol) in methanol (50 ml) was refluxed for 7 days and evaporated to dryness. The residue was chromatographed on a silica gel column eluted with ethyl acetate, and the eluate was evaporated to dryness and recrystallised from propan-2-ol to give 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-3-nitropyrrole (0.96g, 31%) m.p. 161-162°.