Sodium Methoxide → HCID 23325026、化合物

HRID 1732618ノート

反応式

HRID 1732618 の反応式
Cl.[NH2:2][CH2:3][C:4](=O)[CH2:5][CH2:6][CH2:7][CH3:8].[CH3:10][S:11][C:12](S(C)=O)=[CH:13][N+:14]([O-:16])=[O:15].C[O-].[Na+]>CO>[CH3:10][S:11][C:12]1[NH:2][CH:3]=[C:4]([CH2:5][CH2:6][CH2:7][CH3:8])[C:13]=1[N+:14]([O-:16])=[O:15]

参加物

5

反応物 3

HCID 10942334Sodium MethoxideHCID 233250431-Aminohexan-2-one hydrochlorideHCID 544870941-Nitro2-methylthio-2-methylsulphinylethylene

生成物 1

HCID 23325026HCID 23325026、化合物収率 48.5%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒3 回

実験手順

1-Amino-2-hexanone hydrochloride (5.8g) was dissolved in methanol (100 ml) and mixed with a solution of 1-methylthio-1-methylsulphinyl-2-nitroethylene (6.8g) in warm methanol (100 ml). A solution of sodium methoxide in methanol (from 1.7g sodium) was added dropwise, with stirring, over 2 hours at 60°, and the mixture was evaporated to dryness. The residue was triturated with water, and the solid was filtered off and dried, to give 2-methylthio-3-nitro-4-n-butylpyrrole (3.9g).

後処理

  1. customthe mixture was evaporated to dryness
  2. customThe residue was triturated with water
  3. filtrationthe solid was filtered off
  4. customdried

出典と根拠

ORDレコード
ord-7711bf2102ad4720b62e1f6ef17a1793
出典データセット
uspto-grants-1980_12
特許番号
US04238494

反応ノート

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